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May 9, 2026Methods and Applications in Fluorescence0 citationsOpen Access

Compensating Photon Counting Losses in TCSPC SPAD Array for Time-Resolved Imaging

Compensating for photon counting losses in a TCSPC SPAD array enables quantitative time-resolved fluorescence anisotropy imaging

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Authors

LMLouis Nadeem Obeid MogridgeJNJakub NedbalIGIstvan Gyongy

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Overview

Demonstrates improved quantitative time-resolved fluorescence anisotropy imaging, indicating enhanced reliability in imaging technologies.

Key Points

  • The aim is to address photon counting losses in time-correlated single photon counting (TCSPC) systems to enhance imaging accuracy.
  • Developed compensatory techniques for photon counting losses in a TCSPC SPAD array.
  • Utilized histograms to assess the impact of lost photons on quantitative measurements.
  • Employed time-resolved fluorescence anisotropy imaging (TR-FAIM) protocols.
  • Histograms showed minimal effects from lost photons, validating the effectiveness of the compensatory techniques.
  • Quantitative TR-FAIM demonstrated increased reliability and robustness in imaging outcomes.
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Cite This Study

Mogridge et al. (2026) studied this question.

synapsesocial.com/papers/69fecf49b9154b0b828763abhttps://doi.org/10.1088/2050-6120/ae6989
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in wide-field camera-based time-correlated single photon counting fluorescence lifetime imaging2024
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  3. 3Modeling and optimization of time correlated single photon counting accuracy in fluorescence lifetime measurements using delay control2025
  4. 4A time-correlated single photon counting SPAD array camera with a bespoke data-processing algorithm for lightsheet fluorescence lifetime imaging (FLIM) and FLIM videos2024 · 8 citations
  5. 5Near-zero distortion in TCSPC at more than one photon per excitation period: experimental validation2024 · 3 citations