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May 9, 2026Diabetes Obesity and MetabolismOpen Access

Does the Combination of Abdominal Obesity and Vitamin D Deficiency Increase the Risk of Death in Individuals Aged 50 or Older? Evidence From the ELSA Study

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Authors

JMJoyce da Silva MilliatiTSThaís Barros Pereira da SilvaRMRoberta de Oliveira Máximo

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Overview

Randomized trial investigates increased risk of death with abdominal obesity and vitamin D deficiency in older individuals, suggesting the need for early intervention.

Key Points

  • This research aims to determine if the combination of abdominal obesity and vitamin D deficiency leads to a higher risk of death in individuals aged 50 or older.
  • Followed 5,520 participants from the ELSA Study for 6 years.
  • Defined abdominal obesity by waist circumference and assessed vitamin D levels categorically.
  • Used Cox regression models adjusted for various characteristics to estimate mortality risk.
  • The NAO/VDI group had a 91% higher risk of death (HR = 1.91; 95% CI: 1.37-2.66).
  • The AO/VDD group exhibited the highest mortality risk at HR = 2.23 (95% CI: 1.50-3.33).
  • AO associated with vitamin D insufficiency and deficiency led to significant increased mortality risks.

Cite This Study

Milliati et al. (2026) studied this question.

synapsesocial.com/papers/69fecf71b9154b0b828766f9https://doi.org/10.1111/dom.70839
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of abdominal obesity with metabolic multimorbidity and death across glycemic spectrum2025
  2. 2Age-specific benefits of Vitamin D and its association with mortality2025
  3. 3Association Among Vitamin D Supplementation, Serum 25(OH)D Concentrations, and Mortality Risk: A Prospective Cohort Study Using NHANES 2007–2018 Data2024
  4. 4Association of composite dietary antioxidant index (CDAI) with all-cause mortality in adults with abdominal obesity2026
  5. 5Association of Vitamin D Levels and Mortality in Overactive Bladder: Nonlinear Dose–Response and Threshold Effect2026