Objectives/Goals: Linking GAINS evaluates a 14-week community-based program combining genomic testing, ancestry education, and culturally tailored nutrition to improve cardiometabolic health, literacy, and behavior among African American adults in Baton Rouge, Louisiana. Methods/Study Population: Sixty African American adults in Baton Rouge will be randomized into genetically blinded (GB) or unblinded (GU) groups. Both complete baseline surveys, biometric assessments, and a 14-week health behavior program with screenings, nutrition education, cooking classes, and exercise. The GU group receives Color Genomics testing and counseling at baseline; GB receives counseling post-intervention. Follow-up measures assess literacy, diet, and cardiometabolic outcomes. Results/Anticipated Results: CHATGPT SAID: We anticipate improvements in genomic literacy, nutrition knowledge, and willingness to undergo genetic testing, particularly among the unblinded group. Participants are expected to adopt healthier eating and physical activity behaviors, leading to modest reductions in BMI and blood pressure and increased trust in genomics and preventive health research. Discussion/Significance of Impact: Linking GAINS shows how combining genomic testing with culturally tailored nutrition education can improve literacy and lifestyle behaviors, offering a scalable model for advancing equitable precision health in African American communities.
Jennifer Caldwell (2026) studied this question.