Introduction: One of the complications of obesity is increased inflammation, chronic inflammation can cause disease. One of the inflammatory factors that can be effective in the occurrence of inflammation and the development of insulin resistance is (TGF-β, transforming growth factor beta). The present study was conducted to determine the main effect of TRX training and Mixodin supplementation on serum TGF-β levels and insulin resistance in obese women. Material & Methods: The statistical population of the present quasi-experimental study with a pre and post-test design consists of obese women with a mean age (41±2.3 years) and body mass index (31±2.1 kg/m2).The statistical sample included 48 inactive obese women with no history of chronic diseases who were selected from the statistical population to participate in the study after ensuring the inclusion criteria in a voluntary and accessible manner and were randomly assigned to 4 groups: exercise, supplement, supplement + exercise, and control. An 5 cc venous blood sample was taken from the subject in a fasting state (pre-test). After the first sampling, the study groups were subjected to the intervention of TRX training combined with Mixodin supplementation. 48 hours after the last training session, blood sampling was repeated under fasting conditions similar to those before the training period (post-test). The Shapiro-Wilk test was used to determine the normality of data distribution. Two-way analysis of variance was used to examine the effect of exercise, supplement effect, and the interaction effect between the two. The significance level was set at 0.05. Results: The results showed that training significantly reduced TGF-β value and insulin resistance index (P = 0.001), but the main effect of supplementation on any of the variables was not significant (P > 0.05). Also, the effect synergist of training combined with supplementation significantly reduced TGF-β (P = 0.001). Conclusion: It seems that TRX training combined with the use of Mixodin supplement can have a synergistic effect in reducing inflammation and insulin resistance in obese women without any disease.
Rostami et al. (2026) studied this question.