Hypoxia‐induced vulnerability of the somatosensory nervous system

Abstract Hypoxia exerts a strong influence on nervous system behaviour, with its effects most apparent in tissues where metabolic demand is high. This includes the somatosensory system. The stability of metabolic processes within nociceptive neural circuits is essential for their survival and integrity of sensory signalling. These neurones rely heavily on oxygen to maintain fundamental components of neurocommunication. Because of this dependence, pain pathways are particularly vulnerable to even modest reductions in oxygen supply and utilisation that can arise from vascular insufficiency, environmental exposure or systemic conditions including ageing, diabetes, obesity and inherited forms of sensory neuropathy. Reductions in oxygen tissue tension impairs neuronal respiration, leading to a compensatory shift towards less efficient metabolic routes. This transition disrupts cellular energy balance, affects neurocommunication, and can trigger structural and functional changes within sensory circuits. Over time, these alterations contribute to maladaptive processing, modifying how individuals perceive and respond to sensory input. Resulting phenotypes may include heightened sensitivity and/or sensory neurodegeneration, depending on the severity and duration of oxygen limitation. Recognising how hypoxia shapes sensory neurophysiology is particularly important in contexts where pain perception is already altered, such as in ageing or metabolic disease. These conditions often combine impaired perfusion with increased metabolic strain, placing additional pressure on vulnerable sensory neuronal populations. Integrating molecular, metabolic and neurophysiological perspectives emphasises hypoxia as a central driver of nociceptive disturbance and provides a coherent framework for targeting neurometabolic pathways in the treatment of chronic pain. image