Clinical management of osteosarcoma remains a longstanding challenge, largely because of the need for extensive bone reconstruction and the difficulty of balancing treatment with reconstruction. Accumulating evidence indicates that mesoporous bioactive ceramics hold great promise for osteosarcoma therapy. This review systematically analyzes their intrinsic properties, action mechanisms, preparation strategies, and structural regulation, focusing on five key materials: hydroxyapatite, silica, titanium dioxide, magnesium silicate, and perovskite. Mesoporous bioactive ceramics have a high specific surface area and ordered mesoporous channels, enabling efficient drug loading and release. Material modifications—such as surface treatment, ion doping, and various preparation techniques—further enhance these properties. Consequently, these ceramics can serve as smart carriers for chemotherapeutic, photothermal, or antimicrobial agents, while the bioactive ions they release support bone tissue regeneration and remodeling.
Guo et al. (Fri,) studied this question.