slow-release mechanisms to create a "fast-slow biphasic" ionic flow release, thereby establishing a dynamic alkaline ionic flow microenvironment. Within this microenvironment, 5B5Sr-SUIF recruits MSCs and stimulates MSCs to enhance the expression of miR-466m-5p, thereby obstructing the nuclear translocation of NF-κB in macrophages. This facilitates immunological regulatory communication between mesenchymal stem cells and macrophages, offering novel material design principles and molecular mechanism support for the exact regeneration of complicated bone deformities.
Lu et al. (Thu,) studied this question.