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May 9, 2026Sage Open Chronic Disease

Specificity of non-motor symptoms of Parkinson’s disease: A systematic review and meta-analysis

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Authors

HJHolly JacksonJAJudith Anzures-CabreraRARayo Akande

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Overview

Systematic review identifies specific non-motor symptoms of Parkinson’s disease in adults, suggesting better screening methods.

Key Points

  • This research aims to identify non-motor symptoms specific to Parkinson’s disease when compared to controls without neurological diseases.
  • Conducted a systematic review and meta-analysis of 15 studies
  • Included a total of 7393 Parkinson's disease patients and 2742 controls
  • Used random effects model to generate pooled prevalence risk ratios for symptoms.
  • 28 out of 30 non-motor symptoms were more common in the Parkinson’s disease population.
  • Excessive drooling had a risk ratio of 7.30 (95% CI 5.05–10.57).
  • Visual hallucinations showed a risk ratio of 6.48 (95% CI 3.61–11.64).

Cite This Study

Jackson et al. (2026) studied this question.

synapsesocial.com/papers/69fed021b9154b0b828772c9https://doi.org/10.1177/27558428261419700
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