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May 9, 2026Organic & Biomolecular Chemistry0 citations

Palladium catalyzed cross-couplings of trans -vinylboranes with alkyl bromides: a reversed-polarity alternative to B-alkyl Suzuki reactions

PSPetros Danielsen SiapkarasKSKristian SørnesJNJens M. J. Nolsøe

Key Points

  • This research aims to explore an alternative approach to B-alkyl Suzuki reactions using palladium catalysis with vinylboranes and alkyl bromides.
  • Prepared trans-alkenyl-9-BBN derivatives in situ.
  • Utilized palladium catalysis with a tricyclohexylphosphine ligand.
  • Coupled vinylboranes with alkyl bromides.
  • Successfully achieved cross-coupling with high yields.
  • Demonstrated compatibility with various alkyl bromides.
  • Confirmed the effectiveness of the tricyclohexylphosphine ligand in the reactions.

Abstract

A variety of trans -alkenyl-9-BBN derivatives have been prepared in situ and then coupled with alkyl bromides by utilizing palladium catalysis with the electron-rich and sterically encumbered tricyclohexylphosphine ligand.

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Cite This Study

Siapkaras et al. (2026) studied this question.

synapsesocial.com/papers/69fed03cb9154b0b828773c7https://doi.org/10.1039/d6ob00314a
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