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May 9, 2026International Journal of Surgical Pathology0 citations

Invasive Micropapillary Carcinoma of the Breast with an Encapsulated-Like Pattern: An Unreported Entity?

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YAYusuf Aboul-NasrCHClare F HartmanMRMarilin Rosa

Key Points

  • To report a rare case of invasive micropapillary carcinoma with an encapsulated-like pattern and its clinical features.
  • Patient underwent neoadjuvant chemotherapy followed by mastectomy with sentinel lymph node biopsy.
  • Mastectomy revealed a well-circumscribed mass with specific cellular architecture.
  • The mass was 11 cm and surrounded by a fibrous capsule.
  • No lymphovascular invasion was observed in the sentinel lymph nodes, which were negative.

Abstract

positive, HER2-negative]. The patient received neoadjuvant chemotherapy, followed by a mastectomy with sentinel lymph node biopsy. The mastectomy revealed a well-circumscribed 11 cm mass surrounded by a fibrous capsule. The tumor consisted of tubulo-micropapillary structures without fibrovascular cores, lined by a single layer of cuboidal cells containing nests of foamy macrophages. Rare foci of lymphovascular invasion were observed. Two sentinel lymph nodes were negative. To our knowledge, invasive micropapillary carcinoma with an encapsulated pattern has not been previously reported.

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Aboul-Nasr et al. (2026) studied this question.

synapsesocial.com/papers/69fed03cb9154b0b828774f7https://doi.org/10.1177/10668969261444680
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