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May 9, 2026Journal of Agricultural and Food Chemistry0 citations

Design, Synthesis, and Biological Assessment of Potent Covalent Inhibitors of Insect UDP- N -acetylglucosamine Pyrophosphorylase

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XZXingyue ZhouQLQiong LuYZY S Zhang

Key Points

  • The aim is to design and synthesize potent covalent inhibitors of insect UDP-N-acetylglucosamine pyrophosphorylase (UAP).
  • Synthesize various compounds to identify potential UAP inhibitors.
  • Evaluate biological activity of synthesized inhibitors in vitro.
  • Assess structural characteristics influencing inhibitor efficacy.
  • Identified multiple potent covalent inhibitors with significant biological activity.
  • Demonstrated structural features that enhance binding affinity to UAP.

Abstract

. Overall, this study provides a template for designing more UAP inhibitors with covalent characteristics.

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69fed0e2b9154b0b8287807ehttps://doi.org/10.1021/acs.jafc.5c14427
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