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May 9, 2026Journal of the American Chemical Society0 citationsOpen Access

Enantioselective Iridium-Catalyzed Intramolecular Hydroarylation of (Hetero)Arene-Tethered Prochiral Diketones

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AAAndrés ArribasUniversidade de Santiago de CompostelaCLCarlos Lázaro-MillaUniversidade de Santiago de CompostelaMCMartín CalveloUniversidade de Santiago de Compostela

Key Points

  • The aim is to investigate the enantioselective hydroarylation of (hetero)arene-tethered prochiral diketones using iridium catalysts.
  • Utilized SiH as an additive to enhance reaction efficiency.
  • Conducted computational studies to explore the mechanism of the reaction.
  • Investigated stereo-selectivity through a carbometalation pathway.
  • Achieved high enantioselectivity in the hydroarylation process.

Abstract

SiH, an additive that also accelerates the overall transformation. Computational studies support a carbometalation/O-H reductive elimination pathway and shed light on the stereochemical origin of the enantioselectivity.

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Cite This Study

Arribas et al. (2026) studied this question.

synapsesocial.com/papers/69fed140b9154b0b828786f4https://doi.org/10.1021/jacs.6c05640
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