Population
Endothelial cells obtained from different organs and mice (in vivo model)
Design
Preclinical
Authors
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Provides mechanistic insight into Chagas cardiac tropism; hypothesis-generating for FLY-targeted interventions pending human validation.
The FLY peptide motif of T. cruzi gp85/trans-sialidase proteins shows preferential binding to heart vasculature and interacts with intermediate filaments, providing a molecular basis for the parasite's tissue tropism in Chagas disease.
Tonelli et al. (2010) studied this question.