Benzoxazine-Promoted Copper Catalyst for the Activation of the Benzylic C–O Bond: A Homolytic Cleavage without Light

Key Points

• This research aims to explore the reactivity of benzoxazine and copper catalysts in activating the C-O bonds of benzylic alcohols and ethers.
• Combined benzoxazine with copper under mild temperature conditions.
• Investigated the reaction mechanism for radical pathway evidence.
• Analyzed byproducts and product formation rates.
• Successfully activated C-O bonds at mild temperatures.
• Generated benzylic ethers with water as a byproduct.
• Provided mechanistic evidence for radical pathway participation.