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May 10, 2026Nutrition and Health0 citations

trans -Chalcone protects against high-fat diet-induced kidney injury in rats by regulating the miR-874/TLR4 pathway

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EKElham Karimi‐SalesTabriz University of Medical SciencesKHKhalil HajiasgharzadehTabriz University of Medical SciencesMAMohammad Reza AlipourTabriz University of Medical Sciences

Key Points

  • The aim is to evaluate the protective effects of trans-chalcone against kidney injury caused by a high-fat diet via the miR-874/TLR4 pathway.
  • Administered trans-chalcone to rats on a high-fat diet to assess kidney protection.
  • Analyzed changes in the miR-874/TLR4 signaling pathway.
  • Trans-chalcone significantly reduced markers of kidney injury compared to control rats on a high-fat diet.
  • Regulated the expression of miR-874 and TLR4, indicating pathway involvement.

Abstract

-chalcone is a potential therapeutic chalcone for protecting the kidney against the dysregulation of the miR-874/TLR4 pathway during HFD feeding.

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Cite This Study

Karimi‐Sales et al. (2026) studied this question.

synapsesocial.com/papers/6a0020aec8f74e3340f9b759https://doi.org/10.1177/02601060261446821
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