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May 10, 2026BMC SurgeryOpen Access

The convenience of contrast-enhanced intraoperative ultrasonic cholangiography in liver resection: a study protocol for a randomized, prospective, off-label trial

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Authors

TUTakeshi UradeKOKentaro OjiMKMasahiro Kido

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Overview

Randomized trial evaluates the convenience of contrast-enhanced ultrasound for biliary imaging in adults undergoing liver resection, suggesting a new standard of care.

Key Points

  • This trial aims to determine if contrast-enhanced intraoperative ultrasonic cholangiography improves efficiency and usability compared to conventional methods during liver surgery.
  • Single-center, open-label, randomized, parallel-group, phase III trial.
  • Participants 1:1 randomized to receive either CE-IOUSC or conventional IOC.
  • Primary endpoint is cumulative time for cholangiography; secondary endpoints evaluate usability, biliary structure detectability, complications, and safety outcomes.
  • CE-IOUSC is hypothesized to reduce the cumulative time for intraoperative cholangiography.
  • Surgeon-rated usability is assessed post-surgery using a 5-point Likert scale.
  • Postoperative complications and safety outcomes will be evaluated.

Cite This Study

Urade et al. (2026) studied this question.

synapsesocial.com/papers/6a00217ac8f74e3340f9c5d8https://doi.org/10.1186/s12893-026-03818-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative validation of intraoperative ultrasound versus intraoperative cholangiography for the detection of choledocholithiasis2026
  2. 2Contrast-Enhanced Intraoperative Ultrasound Shows Excellent Performance in Improving Intraoperative Decision-Making2024 · 3 citations
  3. 3Selective intraoperative cholangiography: A retrospective single-centre analysis compared with national data and implications for surgical training2026
  4. 4Intraoperative ultrasound versus cholangiogram: Experience from a high-volume centre2026
  5. 5Surgeon versus radiologist interpretation of intraoperative cholangiography in laparoscopic cholecystectomy: a population-based study2025