PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 10, 2026Journal of Nanobiotechnology0 citationsOpen Access

Self-Propelled Nanozyme Motors Target Radiation Cystitis via cfDNA Disruption

Self-propelled nanozyme motors for targeted therapy of radiation cystitis by disrupting the inflammation-cfDNA vicious cycle

View Full Paper
Ask AI
Bookmark
Share

Authors

YHYongbiao HuangYZYang ZhongYYYuanmei Yan

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates targeted therapy for radiation cystitis, suggesting innovative treatment options.

Key Points

  • This study aims to develop a self-propelled nanozyme motor to clear cfDNA and restore redox balance in radiation cystitis.
  • Engineered a self-propelled nanozyme motor operational with endogenous urea.
  • Used intravesical instillation for medicinal delivery and sustained propulsion.
  • Conducted both in vitro and in vivo experiments to assess anti-inflammatory activity.
  • The nanozyme effectively reduced oxidative stress by eliminating reactive oxygen species.
  • Lowered activation of the cGAS-STING pathway and decreased pro-inflammatory cytokines release.
  • Demonstrated substantial mucosal coverage and deeper penetration in therapeutic application.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a0021b7c8f74e3340f9ca25https://doi.org/10.1186/s12951-026-04508-w
View Full Paper
Ask AI
Bookmark
Share