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May 10, 2026SLEEP

0001 Circadian Instability Impacts Brain White Matter and Predicts Future Mania Symptoms in At-Risk Youth

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Authors

JSJoao Paulo Lima SantosLLLara LabardiniLKLauren Keller

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Overview

Randomized trial examines how circadian instability predicts mania symptoms in youth with bipolar risk, suggesting a key intervention target.

Key Points

  • To investigate how circadian instability influences brain white matter and predicts mania symptoms in youth at risk for bipolar disorder.
  • Participants aged 16–24 years (N=112) completed 14 days of actigraphy and a neuroimaging session.
  • Diffusion MRI measured white matter organization, focusing on the uncinate fasciculus and emotion-regulation pathways.
  • Clinician-rated mania and depression were assessed at baseline and after six months.
  • Lower Circadian Function Index (CFI) correlated with higher Orientation Dispersion Index (ODI) in the uncinate fasciculus (β=-0.22, P=0.018).
  • Higher uncinate fasciculus ODI predicted increased mania symptoms at follow-up (β=-0.10, 95% CI[-0.14,-0.02]).
  • No associations were found between sleep duration/onset variability and ODI (P>0.05).

Cite This Study

Santos et al. (2026) studied this question.

synapsesocial.com/papers/6a002222c8f74e3340f9d0b1https://doi.org/10.1093/sleep/zsag091.0001
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