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May 11, 2026Circulation Reports0 citationsOpen Access

Outpatient Guidance and 1-Year Physical Function After Mitral Valve Transcatheter Edge-to-Edge Repair　― An Exploratory Cohort Study ―

YKYuri KamijoYAYoshifumi AbeSMShiori Mori

Key Result

Standardized outpatient guidance at 3 and 6 months after M-TEER was associated with a higher 1-year Short Physical Performance Battery score (12 vs. 8, P=0.034) compared to no guidance.

Key Points

  • Evaluate the impact of structured post-discharge guidance on physical function after mitral valve repair.
  • Observational cohort study with participants receiving outpatient guidance after transcatheter mitral valve repair.
  • Assessment of physical function and activities of daily living over a 1-year follow-up period.
  • Limited evidence found for improved physical function following outpatient guidance.
  • Activities of daily living showed some enhancement, though further investigation is needed.

Study Design

Type

Cohort (n=45)

Multicenter

No

Structured PICO

Does standardized outpatient guidance at 3 and 6 months improve 1-year physical function and activities of daily living in patients after transcatheter mitral valve edge-to-edge repair?

P
Population
45 analyzed patients undergoing transcatheter mitral valve edge-to-edge repair (M-TEER) with MitraClip, median age 81 years, 56% male, 91.1% secondary MR, median Clinical Frailty Scale score 3.
I
Intervention
Standardized outpatient guidance at 3 and 6 months post-discharge (30-40 min sessions delivered by physiotherapists, including feedback on functional assessments, individualized exercise instruction, and lifestyle/self-care counseling).
C
Comparator
No outpatient guidance (neither session).
O
Outcome
1-year Short Physical Performance Battery (SPPB) total score.surrogate

Standardized outpatient guidance at 3 and 6 months after M-TEER is associated with significantly better physical function and activities of daily living at 1 year.

Main Result

Absolute Event Rate: 12% vs 8%

p-value: p=0.034

Limitations

  • Non-random allocation
  • Baseline functional imbalance
  • Selection and survivor bias due to exclusions
  • Residual confounding cannot be excluded
  • Lack of objective data on exercise adherence and physical activity
  • Small non-guidance group limits precision
  • Potential ceiling effects
  • Single-center design limits generalizability
  • Single-center retrospective design
  • Small sample size (45 analyzed out of 108 total patients)
  • Allocation based on operational factors and patient preference (potential selection bias)
  • Findings are exploratory and hypothesis-generating

Abstract

Background: Evidence for structured post-discharge programs to improve long-term physical function and activities of daily living (ADL) after transcatheter mitral valve edge-to-edge repair is limited.

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Cite This Study

Kamijo et al. (2026) conducted a cohort in Severe mitral regurgitation undergoing M-TEER (n=45). Standardized outpatient guidance vs. No guidance was evaluated on 1-year Short Physical Performance Battery (SPPB) total score (p=0.034). Standardized outpatient guidance at 3 and 6 months after M-TEER was associated with a higher 1-year Short Physical Performance Battery score (12 vs. 8, P=0.034) compared to no guidance.

synapsesocial.com/papers/6a0171983a9f334c28271b01https://doi.org/10.1253/circrep.cr-26-0069
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