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May 11, 2026Journal of Medicinal Chemistry0 citations

Preclinical Assessment of a SuFEx-Modified, CAIX-Targeted PET Probe 68 GaGa–SF–DPI-4452 for Imaging Clear Cell Renal Cell Carcinoma

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YCYou ChengYHY Q HuangYZYijin Zou

Key Points

  • This research aims to evaluate a modified PET probe for better imaging of clear cell renal cell carcinoma while minimizing unwanted accumulation in non-target tissues.
  • Conducted biodistribution studies in mice.
  • Performed PET/CT imaging in cynomolgus monkeys.
  • Focused on the effects of SuFEx modification on tumor targeting and off-target uptake.
  • Demonstrated reduced gastrointestinal accumulation of the probe.
  • Confirmed effective tumor targeting with the modified probe.
  • Supported potential for enhanced CAIX-targeted imaging and radionuclide therapy.

Abstract

< 0.05). Biodistribution studies in mice and PET/CT imaging in cynomolgus monkeys further confirmed reduced gastrointestinal accumulation. Overall, SuFEx modification preserves tumor targeting while minimizing off-target uptake, supporting its potential for CAIX-targeted imaging and radionuclide therapy.

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Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/6a0171983a9f334c28271b0dhttps://doi.org/10.1021/acs.jmedchem.6c00678
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