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May 11, 2026Scientific ReportsOpen Access

Effects of voltage-gated sodium channels on the median effective dose of ropivacaine in diabetic rats

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Authors

XSXueyin SongKLKang LvPYPeixia Yu

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Overview

Randomized trial investigates ropivacaine dosing in diabetic rats, revealing lower doses needed for analgesia, indicating sensitivity shifts.

Key Points

  • This study aims to explore how voltage-gated sodium channels affect the median effective dose of ropivacaine in diabetic rats.
  • STZ-induced diabetic rat model used.
  • Dixon up-and-down method determined the ED 50 for sciatic nerve motor block.
  • Measurements included motor nerve conduction velocity and Nav subtypes expression.
  • ED 50 for diabetic rats was 0.100% compared to 0.142% in controls, indicating increased sensitivity.
  • No neurophysiological worsening or histological damage was noted with ropivacaine administration at ED 50.
  • Nav subtypes (Nav1.7, Nav1.8, Nav1.9) and CASPR expression were downregulated in diabetic nerves.

Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/6a0171ce3a9f334c28271d81https://doi.org/10.1038/s41598-026-49845-w
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