What question did this study set out to answer?

To determine if admission serum ferritin levels can predict disease severity in hospitalized pediatric patients.

May 11, 2026Mediators of Inflammation0 citationsOpen Access

Serum Ferritin Levels Predict Severe Disease in Pediatric Hospital Admissions

Admission Serum Ferritin Levels as a Predictor of Severe Disease in Hospitalized Pediatric Patients in Mexico

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Retrospective analysis shows ferritin levels predict severe outcomes in hospitalized children, indicating potential use in clinical settings.

To determine if admission serum ferritin levels can predict disease severity in hospitalized pediatric patients.
Single-center retrospective observational study at a pediatric hospital in Mexico.
Included patients under 16 years old with serum ferritin levels measured on admission.
Developed risk prediction models using receiver operating characteristic (ROC) curves.
Higher admission ferritin levels were significantly associated with the need for vasopressors, blood transfusions, and admission to the pediatric intensive care unit (all p < 0.001).
Ferritin levels >500 ng/mL were linked to longer hospital stays (p = 0.037).
A cut-off of 385 ng/mL was linked to an increased odds ratio (OR 3.21, 95% CI: 1.29–7.97) for mortality.

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Turrubiates-Hernández et al. (2026) studied this question.

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May 11, 2026Mediators of Inflammation0 citationsOpen Access

Admission Serum Ferritin Levels as a Predictor of Severe Disease in Hospitalized Pediatric Patients in Mexico

Authors

Retrospective analysis shows ferritin levels predict severe outcomes in hospitalized children, indicating potential use in clinical settings.

To determine if admission serum ferritin levels can predict disease severity in hospitalized pediatric patients.
Single-center retrospective observational study at a pediatric hospital in Mexico.
Included patients under 16 years old with serum ferritin levels measured on admission.
Developed risk prediction models using receiver operating characteristic (ROC) curves.
Higher admission ferritin levels were significantly associated with the need for vasopressors, blood transfusions, and admission to the pediatric intensive care unit (all p < 0.001).
Ferritin levels >500 ng/mL were linked to longer hospital stays (p = 0.037).
A cut-off of 385 ng/mL was linked to an increased odds ratio (OR 3.21, 95% CI: 1.29–7.97) for mortality.

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Turrubiates-Hernández et al. (2026) studied this question.

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View Full Paper