The highest tertile of the Triglyceride-glucose (TyG) index was significantly associated with high carotid intima-media thickness compared to the lowest tertile (OR 1.73) in young adults.
Cross-Sectional (n=1,339)
Is a higher Triglyceride-glucose (TyG) index associated with increased carotid intima-media thickness in young adults?
The TyG index exhibits a modest relationship with higher CIMT levels, suggesting its potential utility as a surrogate marker for early atherosclerosis in young adults.
Effect estimate: OR 1.73
BACKGROUND: The association of the Triglyceride-glucose (TyG) index as a novel surrogate marker of IR with atherosclerotic CVD has been suggested previously. However, there is limited data available for young adults. We aimed to define the association of the TyG Index and the carotid intima-media thickness (CIMT) in the Tehran, Lipid and Glucose Study (TLGS). METHODS: In this cross-sectional study, 1339 participants aged ≥ 18 were categorized into three tertiles based on the TyG Index. The totel effect of TyG Index tertiles on CIMT and high CIMT were investigated in multiple linear regression and logistic regression models, respectively. RESULTS: The mean age of 1339 participants enrolled in the study was 29.77 ± 4.0 years (52% men). The participants were categorized into three tertiles based on the TyG Index. The odds ratio (OR) for the association of TyG Index tertiles with high CIMT was significant in tertile 3 in reference to tertile one after adjustment to age and sex (model 1; OR = 1.73, CONCLUSION: Our results indicate that the TyG index exhibits a modest overall relationship with higher CIMT levels. These results highlight the potential role of the TyG index as an independent novel variable linked to early atherosclerosis in young adults.
Seyedhoseinpour et al. (Sat,) conducted a cross-sectional in Early atherosclerosis (n=1,339). Triglyceride-glucose (TyG) index (Tertile 3) vs. TyG index (Tertile 1) was evaluated on High carotid intima-media thickness (CIMT) (OR 1.73). The highest tertile of the Triglyceride-glucose (TyG) index was significantly associated with high carotid intima-media thickness compared to the lowest tertile (OR 1.73) in young adults.