Handheld mobile ECG devices (KardiaMobile 1 L and 6 L) demonstrated excellent agreement with standard 12-lead ECGs for QTc assessment in cLQTS patients, with mean biases < 10 ms.
Observational (n=102)
Do handheld mobile ECG devices accurately measure QTc compared to standard 12-lead ECGs in patients with congenital long QT syndrome?
Handheld mobile ECG devices (KardiaMobile 1L and 6L) show excellent agreement with standard 12-lead ECGs for QTc assessment in patients with congenital long QT syndrome, supporting their potential use for remote monitoring.
Effect estimate: Mean bias < 10 ms
INTRODUCTION: Handheld mobile ECG (mECG) devices offer potential for remote QTc surveillance in congenital long QT syndrome (cLQTS), but validation against standard 12‑lead ECGs is limited. METHODS AND RESULTS: We studied 102 cLQTS patients (median age 36), using consecutive 12‑lead ECGs and KardiaMobile 1 L and 6 L recordings. Agreement with 12‑lead ECGs was assessed using Lin's concordance correlation coefficient (CCC) and Bland-Altman analysis. Mean biases were < 10 ms, within the predefined threshold for excellent agreement. Reproducibility was high. CONCLUSION: These findings support the cautious integration of mECG-based QTc monitoring for high-risk cLQTS patients.
Steijn et al. (2026) conducted an observational in Congenital long QT syndrome (cLQTS) (n=102). Handheld mobile ECG (KardiaMobile 1 L and 6 L) vs. Standard 12-lead ECG was evaluated on Agreement of QTc assessment between mobile ECG and 12-lead ECG (Mean bias < 10 ms). Handheld mobile ECG devices (KardiaMobile 1 L and 6 L) demonstrated excellent agreement with standard 12-lead ECGs for QTc assessment in cLQTS patients, with mean biases < 10 ms.