Mortality due to ventricular arrhythmias with congestive heart failure declined from an age-adjusted rate of 1.8 per 100,000 in 1999 to 0.9 in 2024 (AAPC: -2.36%; p<0.001).
Observational (n=60,968)
Yes
While mortality from ventricular arrhythmias and congestive heart failure decreased overall from 1999 to 2024, rates have been increasing since 2008, with persistent disparities by race, sex, age, and geography.
Effect estimate: AAPC -2.36%
p-value: p=<0.001
BACKGROUND: Congestive heart failure (CHF) complicated by ventricular arrhythmias (VA) continues to account for substantial mortality. Nevertheless, national-level longitudinal evidence on mortality trends remains limited. This study investigates these patterns among U.S. adults aged ≥ 25 years across years 1999–2024. METHODS: An observational analysis of U.S. mortalities due to VA with CHF (ICD-10 I47.2, I49.0 and I50.0 respectively), was conducted using CDC WONDER. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated, and temporal trends were evaluated using annual percent change (APC) and average annual percent change (AAPC), stratified by year, age, sex, race, and geographic region. RESULTS: Between 1999 and 2024, 60,968 deaths were accounted for VA with CHF. Overall, AAMR declined from 1.8 in 1999 to 0.9 in 2024 (AAPC: − 2.36%; p < 0.001). A sharp decline occurred from 1999 to 2008 (APC: − 8.07; p < 0.001), followed by a significant increase afterwards (APC: 1.01; p = 0.0036). AAMRs were higher in men than women (1.7 vs. 0.6). Older adults showed greatest AAMRs (4.5) compared with middle-aged (0.5) and younger adults (0.1). By race, Non-Hispanic (NH) Blacks exhibited the highest mortality rates (1.4), followed by Whites (1.1), Hispanics (0.7), and NH Others (0.6). Geographically, West Virginia recorded the highest AAMR (1.8) versus New York (0.7). The West, Midwest, and South shared similar rates (1.1), whereas the Northeast was lowest (0.8). Rural populations demonstrated higher AAMRs than urban (1.2 vs. 1.0). CONCLUSION: Although VA-CHF mortality has decreased over the past two decades, disparities by race, sex, age, and geography persist, underscoring the need for targeted healthcare strategies.
Naveed et al. (2026) conducted an observational in Ventricular arrhythmias and congestive heart failure (n=60,968). Mortality due to ventricular arrhythmias with congestive heart failure declined from an age-adjusted rate of 1.8 per 100,000 in 1999 to 0.9 in 2024 (AAPC: -2.36%; p<0.001).