Recent studies establish a reciprocal crosstalk between the endothelium and adipose tissue in obesity, linking their respective pathologies and motivating multimechanism therapies for cardiometabolic diseases.
Vasculature and surrounding adipose tissue constitute a dynamic interface, maintaining cardiometabolic homeostasis. Obesity rewires this crosstalk into a self-perpetuating cycle. Two recent studies by Suda et al. and Hof et al., respectively, established the 'endothelium-to-adipose' and 'adipose-to-endothelium' arms, linking endothelial and adipose pathology and motivating multimechanism therapies for cardiometabolic diseases.
Ch et al. (2026) conducted an editorial in cardiometabolic diseases. Recent studies establish a reciprocal crosstalk between the endothelium and adipose tissue in obesity, linking their respective pathologies and motivating multimechanism therapies for cardiometabolic diseases.