March 31, 2026Saudi Medical Journal0 citationsOpen Access

Bleeding Avoidance Strategies in Patients with Atrial Fibrillation

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Atrial Fibrillation (n=1516). Intervention: Left atrial appendage occlusion vs. Oral anticoagulants. Primary outcome: Cardiovascular mortality (RR 0.65, 95% CI 0.44 to 0.95, p=0.03).

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Population

Patients with atrial fibrillation, including those with concomitant coronary artery disease requiring…

Comparison

Bleeding avoidance strategies, including… vs Standard of care.

Design

Editorial

Key result

Left atrial appendage occlusion significantly reduced cardiovascular mortality (RR 0.65) compared with oral anticoagulants in patients with nonvalvular atrial fibrillation.

Authors

ALAntonio Landi MVMarco Valgimigli

Discussion

Member takes

Overview

May inform LAAO decisions in nonvalvular AF; hypothesis-generating and leaves open randomized confirmation.

Structured PICO

Population

Patients with atrial fibrillation, including those with concomitant coronary artery disease requiring percutaneous coronary intervention and those at high bleeding risk.

Intervention

Bleeding avoidance strategies, including shortened triple antithrombotic therapy, P2Y12 inhibitor monotherapy, and transcatheter left atrial appendage occlusion (LAAO).

Comparator

Standard of care (e.g., prolonged triple antithrombotic therapy or long-term oral anticoagulation).

Limiting the duration and number of concomitant antithrombotic therapies, or utilizing LAAO, are essential strategies to balance ischemic and bleeding risks in patients with atrial fibrillation.

Main Result

Effect estimate: RR 0.65 (95% CI 0.44 to 0.95)

p-value: p=0.03

Cite This Study

Landi et al. (2026) conducted an editorial in Atrial Fibrillation (n=1,516). Left atrial appendage occlusion vs. Oral anticoagulants was evaluated on Cardiovascular mortality (RR 0.65, 95% CI 0.44 to 0.95, p=0.03). Left atrial appendage occlusion significantly reduced cardiovascular mortality (RR 0.65) compared with oral anticoagulants in patients with nonvalvular atrial fibrillation.

synapsesocial.com/papers/6a025ce3edf6f48138594acb https://doi.org/10.15537/1658-3175.1000

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March 31, 2026Saudi Medical Journal0 citationsOpen Access

Bleeding Avoidance Strategies in Patients with Atrial Fibrillation

View Full Paper

Ask AI

Bookmark

Population

Patients with atrial fibrillation, including those with concomitant coronary artery disease requiring…

Comparison

Bleeding avoidance strategies, including… vs Standard of care.

Design

Editorial

Key result

Left atrial appendage occlusion significantly reduced cardiovascular mortality (RR 0.65) compared with oral anticoagulants in patients with nonvalvular atrial fibrillation.

Authors

ALAntonio Landi MVMarco Valgimigli

Discussion

Member takes

Overview

May inform LAAO decisions in nonvalvular AF; hypothesis-generating and leaves open randomized confirmation.

Structured PICO

Population

Patients with atrial fibrillation, including those with concomitant coronary artery disease requiring percutaneous coronary intervention and those at high bleeding risk.

Intervention

Bleeding avoidance strategies, including shortened triple antithrombotic therapy, P2Y12 inhibitor monotherapy, and transcatheter left atrial appendage occlusion (LAAO).

Comparator

Standard of care (e.g., prolonged triple antithrombotic therapy or long-term oral anticoagulation).

Limiting the duration and number of concomitant antithrombotic therapies, or utilizing LAAO, are essential strategies to balance ischemic and bleeding risks in patients with atrial fibrillation.

Main Result

Effect estimate: RR 0.65 (95% CI 0.44 to 0.95)

p-value: p=0.03

Cite This Study

synapsesocial.com/papers/6a025ce3edf6f48138594acb https://doi.org/10.15537/1658-3175.1000

View Full Paper

Ask AI

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