17β-estradiol mitigated pathological microtubule remodeling, increased tricuspid plane annular systolic excursion, and enhanced right ventricular-pulmonary artery coupling in preclinical rat models.
Does 17β-estradiol improve right ventricular function and mitigate pathological microtubule remodeling in preclinical models of pulmonary hypertension?
Preclinical models including iPSC-cardiomyocytes, male rats with pulmonary artery banding (PAB), and female monocrotaline rats (intact and oophorectomized).
17β-estradiol (in vitro: 20 nM and 200 nM; in vivo: administered for two weeks starting two weeks after pulmonary artery banding, and exogenous administration in monocrotaline rats).
Vehicle (ethanol in vitro, PAB-Vehicle in vivo) and oophorectomized females without exogenous 17β-estradiol.
Microtubule polymerization kinetics, microtubule density, tricuspid plane annular systolic excursion (TAPSE), right ventricular (RV) free wall thickening, and estimated RV-pulmonary artery coupling.surrogate
In preclinical models of pulmonary hypertension, 17β-estradiol counteracts pathological microtubule remodeling and enhances right ventricular function, suggesting a novel cardioprotective mechanism.
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Ryan Moon
Rafael Sobrano Fais
Minwoo Kim
Journal of Clinical Investigation
University of Minnesota
University of Colorado Denver
Medical University of South Carolina
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Moon et al. (Thu,) conducted a other in Right ventricular dysfunction and pulmonary hypertension. 17β-estradiol vs. Vehicle (ethanol/alcohol) or control was evaluated on Right ventricular function (TAPSE, RV free wall thickening, RV-PA coupling) and microtubule density. 17β-estradiol mitigated pathological microtubule remodeling, increased tricuspid plane annular systolic excursion, and enhanced right ventricular-pulmonary artery coupling in preclinical rat models.
www.synapsesocial.com/papers/6a025efdc9581ed855361b3d — DOI: https://doi.org/10.1172/jci201385