Randomized trial finds changes in proteinuria predict risk of dialysis-requiring AKI and ESRD in Koreans, suggesting a need for monitoring.
Key Points
This research investigates the relationship between changes in urine protein levels and the risk of severe acute kidney injury (AKI) leading to end-stage renal disease (ESRD).
Included 2,021,548 Koreans who underwent health check-ups in 2005-2006 and 2009.
Categorized changes in proteinuria into four groups based on urine dipstick test results.
Assessed adjusted hazard ratios and 95% confidence intervals for dialysis-requiring AKI and subsequent ESRD over a median follow-up of 11.84 years.
The risk for dialysis-requiring AKI was highest in persistent proteinuria (HR 3.643 [2.881-4.607]), followed by incident (HR 1.922 [1.694-2.181]) and resolved proteinuria (HR 1.453 [1.194-1.767]).
The risk for ESRD also increased with persistent proteinuria (HR 22.883 [15.067-34.755]), incident (HR 7.508 [5.548-10.163]), and resolved (HR 4.813 [2.970-7.800]) compared to negative proteinuria.
All patterns of change in proteinuria were significantly linked to an increased risk of dialysis-requiring AKI and ESRD.