without the need for added molecular hydrogen-atom-transfer reagents, soluble metal redox couples, or strong acids/bases. Mechanistic studies indicate that the grafted TEMPO not only participates in oxidation chemistry but also reshapes the carbon framework by introducing carbonyl groups, which modulate the electronic structure and lower the spin state of the iron centers. These coupled electronic and spin effects promote oxygen activation, thereby promoting the formation and release of reactive superoxide species that drive selective toluene oxidation. This strategy provides a cleaner platform for aerobic electrooxidation and offers a design principle for selective oxidation catalysis powered by electricity.
Tan et al. (2026) studied this question.