PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
May 13, 2026

Dyspnea and fatigue in Long-COVID: definition of risk factors and of DLCO-based phenotypes in a multicenter study of 765 patients from Italy.

View Full Paper
Ask AI
Bookmark
Share

Authors

MFMarco FloridiaLWLiliana Elena WeimerAFAldo Lo Forte

Discussion

Loading...

Member takes

Overview

Multicenter study identifies risk factors associated with dyspnea and fatigue in long-covid, implying the need for pulmonary evaluation.

Key Points

  • This study aimed to evaluate dyspnea and fatigue in relation to pulmonary function and exercise capacity among long-covid patients.
  • Multicenter cohort study of 765 long-covid patients in Italy.
  • Utilized multivariable analyses to characterize dyspnea and fatigue phenotypes.
  • Assessed exercise capacity with the six-minute walk distance (6MWD).
  • 41.3% of patients reported dyspnea and 41.6% reported fatigue after 6 months post-COVID-19.
  • Approximately 51.6% of patients with dyspnea and 54.7% with fatigue had normal pulmonary function based on DLCO testing.
  • Low-DLCO dyspnea linked to female sex, anxiety, and hospitalization duration, while normal-DLCO dyspnea associated with younger age and obesity.
  • Low-DLCO fatigue correlated with female sex, heart failure, and corticosteroid use.

Cite This Study

Floridia et al. (2026) studied this question.

synapsesocial.com/papers/6a03cb781c527af8f1ecf2bfhttps://doi.org/10.1016/j.rmed.2026.108880
View Full Paper
Ask AI
Bookmark
Share