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May 13, 2026Journal of Medical MicrobiologyOpen Access

Procalcitonin kinetics in Gram-negative bloodstream infections and its value for infection management

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Authors

SASaied AliNMNiamh MullaneNRNicki Rees

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Overview

Cohort study evaluates procalcitonin and C-reactive protein's role for antimicrobial management in Gram-negative bloodstream infections, suggesting limited utility.

Key Points

  • To evaluate early procalcitonin changes in relation to antimicrobial appropriateness and source control in Gram-negative bloodstream infections.
  • Cohort study of 170 hospitalized adults with Enterobacterales BSIs
  • Measured serum procalcitonin and C-reactive protein at blood culture positivity and serially on days 2 and 5
  • Applied non-parametric methods for biomarker kinetics analysis
  • Used multivariable logistic regression for associations between baseline biomarkers and illness severity
  • Median baseline procalcitonin was 5.81 ng ml−1 and C-reactive protein 124.1 mg l−1
  • Both biomarkers increased from day 0 to day 2 and declined by day 5 (P<0.001)
  • Baseline procalcitonin was associated with ICU admission and higher Sequential Organ Failure Assessment scores
  • Neither procalcitonin nor C-reactive protein kinetics were associated with 30-day mortality

Cite This Study

Ali et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbbe1c527af8f1ecf8fchttps://doi.org/10.1099/jmm.0.002168
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of procalcitonin levels with multidrug-resistant bloodstream infections: a prospective cohort study2026
  2. 2Diagnostic performance of procalcitonin for predicting bloodstream infection and guidance on microbial aetiology: a prospective study at an Egyptian tertiary care hospital2026
  3. 3Procalcitonin and C-reactive Protein in Septicaemia: Correlation With Bacterial Profile and Antimicrobial Resistance in ICU Setting2026
  4. 4Diagnostic utility of procalcitonin in determining Gram-negative and Gram-positive bacterial bloodstream infections: a single-centre study from South India2026
  5. 5Procalcitonin-Guided Antibiotic Therapy in Adult Sepsis: A Biochemical Perspective from a Retrospective Cohort Study2025 · 1 citations