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May 13, 2026Diabetology & Metabolic SyndromeOpen Access

Obesity and respiratory diseases: mechanisms, phenotypes, and clinical implications

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Authors

ASA M SolimanAAAmany AbouzeidHAHebatallah H. Ahmed

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Overview

Comprehensive review links obesity to increased respiratory disorders and mortality, highlighting distinct phenotypes and pathways.

Key Points

  • This review explores the mechanisms by which obesity impacts respiratory health and identifies distinct clinical phenotypes.
  • Conducted a narrative review of literature from PubMed/MEDLINE, Embase, and Cochrane Database.
  • Focused on the relationship between obesity and respiratory disorders including asthma, sleep apnea, and COPD.
  • Employed pre-specified MeSH terms and followed SANRA guidelines for quality assessment.
  • Obesity is associated with increased morbidity and mortality related to respiratory diseases.
  • Distinct phenotypes such as asthma subtypes identified, correlating with obesity.
  • Emerging pharmacological therapies show promise in improving conditions like obstructive sleep apnea.

Cite This Study

Soliman et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbe01c527af8f1ecfa50https://doi.org/10.1186/s13098-026-02164-6
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