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May 13, 2026Journal of Cell Communication and SignalingOpen Access

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

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Authors

HSHongqin SunHSHao ShuQZQian Zhang

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Overview

Review reveals HGF/c-Met pathway's role in tumor progression and diseases like diabetes and Alzheimer’s, implying therapeutic targeting potential.

Key Points

  • To review the HGF/c-Met signaling pathway and its implications in various human diseases.
  • Systematically synthesize recent research data on HGF/c-Met pathway mechanisms.
  • Discuss potential therapeutic strategies targeting c-Met and HGF.
  • Evaluate challenges in clinical translation, including specificity and drug resistance.
  • HGF/c-Met pathway is crucial for embryonic development and tissue homeostasis.
  • Dysregulation is linked to malignant tumor progression and various diseases.
  • Therapeutic strategies include c-Met inhibitors and microRNA regulation.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbfc1c527af8f1ecfc2chttps://doi.org/10.1002/ccs3.70075
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