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May 13, 2026Genetics ResearchOpen Access

Identification and Validation of Mitophagy‐Related Biomarkers in Colorectal Cancer: An Integrated Analysis of Single‐Cell Transcriptome and Mendelian Randomization

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Authors

JZJ. Y. ZhaoMKMeng KongSWSining Wang

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Overview

Integrated analysis identifies mitophagy-related biomarkers in colorectal cancer, suggesting links to genetic causation.

Key Points

  • This research aims to identify mitophagy-related biomarkers and their genetic relevance in colorectal cancer (CRC).
  • Integrated analysis of single-cell RNA sequencing and Mendelian randomization
  • Differential expression and machine learning utilized to identify biomarkers
  • Validation of gene expression through quantitative PCR in clinical samples
  • Identified 147 mitophagy-related differentially expressed genes (DE-MPGs)
  • Three biomarkers: SGCE, ATP8B2, and RANGAP1 showed significant expression changes in CRC
  • Mendelian randomization analysis revealed genetic causal relevance for identified biomarkers.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbfc1c527af8f1ecfd2chttps://doi.org/10.1155/genr/5579542
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