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May 13, 2026Expert Opinion on Therapeutic Targets

Identifying targets at the blood-brain barrier for treating vascular cognitive impairment and dementia

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Authors

AAAdnan AkifUniversity of Nevada, RenoTNThi Thanh My NguyenUniversity of HoustonBHBenjamin L. HaoSt Clements University Higher Education School

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Overview

This review evaluates strategies addressing blood-brain barrier dysfunction in vascular cognitive impairment, suggesting precision medicine can enhance outcomes.

Key Points

  • The aim is to identify and evaluate approaches targeting the blood-brain barrier for managing vascular cognitive impairment and dementia.
  • Reviewed recent advances linking blood-brain barrier dysfunction to vascular cognitive impairment.
  • Summarized pharmacological and cellular strategies to restore blood-brain barrier function.
  • Evaluated innovative delivery platforms like focused ultrasound and nanocarriers.
  • Established connection between blood-brain barrier dysfunction and cognitive decline.
  • Highlighted effective pharmacological agents targeting oxidative stress and inflammation.
  • Proposed precision medicine approaches for vascular risk control and regenerative therapies.

Cite This Study

Akif et al. (2026) studied this question.

synapsesocial.com/papers/6a03cc1b1c527af8f1ecffaahttps://doi.org/10.1080/14728222.2026.2671696
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