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May 13, 2026Immunopharmacology and Immunotoxicology

Alyssin modulates inflammatory mediator expression in TNF-α-stimulated human periodontal ligament cells

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Authors

IHIkuko HosokawaYHYoshitaka HosokawaRORisa Okamoto

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Overview

Randomized trial investigates alyssin's impact on inflammatory mediators in periodontal cells, suggesting therapeutic potential.

Key Points

  • This study aims to evaluate the anti-inflammatory effects of alyssin on human periodontal ligament cells stimulated by TNF-α.
  • Cytokine production in supernatant was measured using ELISA.
  • Western blot analysis was performed to examine signal transduction pathways and intracellular protein expression.
  • Alyssin suppressed TNF-α-induced production of IL-6 and CCL20 in human periodontal ligament cells.
  • Expression of ICAM-1 and COX-2 was inhibited by alyssin treatment in HPDLCs.
  • Alyssin enhanced the expression of antioxidant enzymes such as Nrf2, HO-1, and NQO1 in HPDLCs.

Cite This Study

Hosokawa et al. (2026) studied this question.

synapsesocial.com/papers/6a04147679e20c90b444473dhttps://doi.org/10.1080/08923973.2026.2671723
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