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May 13, 2026Physiological Reviews

Impact of gastric emptying and small intestinal carbohydrate absorption on glycemia in health and diabetes: therapeutic implications

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Authors

RJRyan J. JallehTWTongzhi WuMUMahesh M. Umapathysivam

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Overview

Review highlights how gastric emptying affects glycemia in diabetes, suggesting new therapeutic strategies.

Key Points

  • This work aims to elucidate the relationship between gastric emptying, carbohydrate absorption, and glycemic control in health and diabetes.
  • Comprehensive review of gastric emptying dynamics and its effects on glycemia.
  • Analysis of incretin hormones and their role in regulating gastric emptying.
  • Assessment of current therapies targeting gastric emptying for diabetes management.
  • Delayed gastric emptying significantly contributes to postprandial hyperglycemia in diabetes.
  • Incretin hormones like GLP-1 and PYY demonstrate critical influence on gastric emptying.
  • Advances in understanding these interactions can enhance diabetes management practices.

Cite This Study

Jalleh et al. (2026) studied this question.

synapsesocial.com/papers/6a04153d79e20c90b44450dbhttps://doi.org/10.1152/physrev.00009.2025
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