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May 14, 2026Journal of Pain Research0 citationsOpen Access

Liposomal Bupivacaine Infiltration and Postoperative Pain Outcomes in Lumbar Fusion: A Prospective Randomized Controlled Trial Response to Letter

SZShi-Jing ZhangXLXin LuTLTian-Xiao Liu

Key Points

  • The aim is to assess the impact of liposomal bupivacaine infiltration on postoperative pain outcomes after lumbar fusion surgery.
  • Conducted a prospective randomized controlled trial with specified primary endpoint as 24-hour resting VAS score.
  • Sample size determined based on the primary endpoint and compared between LB+B and RH groups.
  • Estimated marginal mean resting VAS score was 1.14 for LB+B group and 1.30 for RH group, with a between-group difference of 0.15 (95% CI, -0.21 to 0.52; P = 0.406).
  • No statistically significant or clinically meaningful difference was observed between the two treatments.

Abstract

A Prospective Randomized Controlled Trial".We also appreciate their interest in our work.We would also like to thank the authors for their interest in our paper and for taking the time to express their views, here are our responses to each of the suggestions they raised. The Prespecified 24-Hour Resting VAS EndpointWu and Jiang state that the prespecified primary endpoint, the 24-hour resting VAS score, was not directly reported as a between-group comparison.This assertion is not supported by the published record.The article explicitly identified the resting VAS score at 24 hours postoperatively as the prespecified primary endpoint used for sample-size determination, while repeated postoperative pain assessments were described separately as secondary or exploratory outcomes.The corresponding 24-hour contrast was reported in Supplementary Table S2.The estimated marginal mean resting VAS score was 1.14 (95% CI, 0.92-1.37) in the LB+B group and 1.30 (95% CI, 1.01-1.58) in the RH group, with a between-group difference of 0.15 points (95% CI, -0.21 to 0.52; P = 0.406; Holm-adjusted p = 1.000).These findings show neither a statistically significant difference nor a clinically meaningful separation between groups.The primary endpoint was therefore not omitted; it was reported in the supplementary material, which forms part of the published article.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a05659da550a87e60a1df5ehttps://doi.org/10.2147/jpr.s621441
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