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May 14, 2026Organic & Biomolecular Chemistry0 citations

Diverse Structural Roles of Ferrocene in Mediating Ferroptosis Induction by ML162

JWJing WangWLWei LiZZZeqi Zhu

Key Points

  • This research aims to explore how ferrocene influences the induction of ferroptosis through GPX4 modulation.
  • Investigation of diverse structural roles of ferrocene derivatives.
  • Examination of iron-dependent cell death processes using in vitro models.
  • Ferrocene derivatives significantly enhance ferroptosis induction.
  • Covalent inhibitors targeting GPX4 reduce cell resistance to iron-induced death.

Abstract

Ferroptosis, an iron-dependent form of regulated cell death, represents a compelling target for cancer therapy. A key cellular defense is mediated by glutathione peroxidase 4 (GPX4), where covalent inhibitors like...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a05661aa550a87e60a1e2cbhttps://doi.org/10.1039/d6ob00389c
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