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May 14, 2026Physiology

Role of intestinal epithelial-specific c-jun N-terminal kinase 2 (JNK2) in alcohol-induced tissue injury at the gut-liver axis

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Authors

NJNathan JonesNSNitesh ShashikanthPRPreeti Raju

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Overview

Randomized trial investigates JNK2's role in alcohol-induced gut damage, suggesting treatment pathways.

Key Points

  • This research aims to understand how JNK2 contributes to alcohol-induced damage in the gut-liver axis.
  • Utilized enteroids from wild-type and JNK2 knockout mice, exposing them to ethanol and acetaldehyde.
  • Measured intestinal permeability with FITC-inulin in vivo over multiple alcohol concentrations.
  • Conducted experiments with JNK2 knockout models to assess resistance to alcohol toxicity.
  • Ethanol and acetaldehyde activated JNK2 transiently, peaking at one hour post-treatment.
  • JNK2 knockout enteroids showed resilience to alcohol toxicity, maintaining their structural integrity.
  • Chronic ethanol feeding reduced body weight in wild-type mice, while JNK2 knockout mice remained resistant to weight loss up to 5% ethanol.

Cite This Study

Jones et al. (2026) studied this question.

synapsesocial.com/papers/6a05661aa550a87e60a1e2fbhttps://doi.org/10.1152/physiol.2026.41.s1.2300288
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