Community cohort study investigates phenylalanine-BAIBA metabolic axis, revealing its role in muscle function and aging.
Key Points
This study aims to explore the role of the phenylalanine-BAIBA metabolic axis in age-related cardio-sarcopenia.
Community cohort study with n=400 from ASHA aged 55-85
Quantification of plasma phenylalanine and BAIBA via LC-MS/MS
Cellular experiments on cardiac and skeletal muscle cells focusing on phenylalanine's effects
Higher serum phenylalanine levels correlate with increased myosteatosis (r=0.88, p<0.004) and reduced physical function scores (SPPB, p<0.008)
Phenylalanine levels were associated with cardiac remodeling markers, including increased LV mass (r=0.67, p<0.048) and higher concentricity index (r=0.71, p<0.05)
BAIBA treatment reversed phenylalanine-induced apoptosis in cardiac and skeletal myocytes, upregulating protective genes.