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May 14, 2026Advanced ScienceOpen Access

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

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Authors

YLYueyuan LiuCHChenhui HanCXCheng Xue

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Overview

Randomized trial analyzes 3D genomic structures in pear species, revealing gene expression impacts on leaf traits.

Key Points

  • The aim is to explore the significance of 3D chromatin architecture in gene regulation across different pear species.
  • Developed high-resolution Hi-C maps of Pyrus species with approximately 5 kb resolution.
  • Compared 3D genomic architecture of three pear species: P. betuleafolia, P. bretschneideri, and P. communis.
  • Analyzed variations in TAD-like boundaries and their correlation with gene expression levels.
  • Approximately 78% of compartment and 73% of TAD-like domains are conserved across all species.
  • Structural variations in TAD-like boundaries correlated with different genes' expression levels and pathways.
  • Identified candidate gene PyYABBY associated with enhanced leaf size variation between specific pear species.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a056714a550a87e60a1f144https://doi.org/10.1002/advs.202519321
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