What question did this study set out to answer?

To evaluate the cytotoxic effects of Begonia malabarica hydroalcoholic extract on HepG2 cancer cell lines.

Phytochemical profiling and cytotoxic potential of hydroalcoholic extract of Begonia malabarica in HepG2 cells: an in vitro phytopharmacological study

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In vitro study demonstrates significant apoptosis in HepG2 cells using hydroalcoholic extract, indicating cancer treatment potential.

To evaluate the cytotoxic effects of Begonia malabarica hydroalcoholic extract on HepG2 cancer cell lines.
Assessed cytotoxicity in HepG2 cells using Annexin V/PI Apoptotic assay.
Compared results with doxorubicin, a standard anti-cancer drug.
Extract induced 70.56% late apoptosis in HepG2 cells, similar to doxorubicin's 71.2%.
22.17% of the cells were dead, while only 0.04% were early apoptotic.
Results indicate potential mechanisms of mitochondrial disruption and oxidative stress.

Chediyankandy et al. (2026) studied this question.

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View Full Paper

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Authors

In vitro study demonstrates significant apoptosis in HepG2 cells using hydroalcoholic extract, indicating cancer treatment potential.

To evaluate the cytotoxic effects of Begonia malabarica hydroalcoholic extract on HepG2 cancer cell lines.
Assessed cytotoxicity in HepG2 cells using Annexin V/PI Apoptotic assay.
Compared results with doxorubicin, a standard anti-cancer drug.
Extract induced 70.56% late apoptosis in HepG2 cells, similar to doxorubicin's 71.2%.
22.17% of the cells were dead, while only 0.04% were early apoptotic.
Results indicate potential mechanisms of mitochondrial disruption and oxidative stress.

Chediyankandy et al. (2026) studied this question.

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