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May 14, 2026Physiology

Segmental pulmonary vascular remodeling in heart failure induced by chronic volume overload

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Authors

TNTomáš NovákVMVojtěch MelenovskýMMMatúš Miklovič

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Overview

Randomized trial examines pulmonary vascular changes in rats with volume overload, suggesting mechanisms behind pulmonary hypertension.

Key Points

  • The study aims to investigate how chronic volume overload affects pulmonary vascular resistance distribution and structure.
  • Induced aortocaval fistula in Sprague-Dawley rats and analyzed pulmonary hemodynamics ex vivo.
  • Measured total pulmonary vascular resistance and segmental pressure drops in isolated lungs.
  • Assessed vasoreactivity to hypoxia, angiotensin II, and norepinephrine.
  • The ACF group showed lower total pulmonary vascular resistance (0.05 ± 0.01 vs. 0.09 ± 0.04 mmHg·min·ml - ¹·kg, P < 0.05).
  • Significant declines in capillary pressure drop (0.8 ± 0.7 vs. 3.1 ± 1.1 mmHg, P < 0.05) and venous pressure drop (0.7 ± 1.5 vs. 2.8 ± 1.2 mmHg, P < 0.05).
  • Lung dry weight increased in ACF group, indicating structural remodeling (0.13 ± 0.02 vs. 0.10 ± 0.01 g, P = 0.01).

Cite This Study

Novák et al. (2026) studied this question.

synapsesocial.com/papers/6a0567fda550a87e60a203c6https://doi.org/10.1152/physiol.2026.41.s1.2298872
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temporal evaluation of left ventricular remodeling and function in rats with chronic volume overload1996 · 115 citations
  2. 2Temporal pattern of left ventricular structural and functional remodeling following reversal of volume overload heart failure2011 · 62 citations
  3. 3Chronic Elevation of Pulmonary Microvascular Pressure in Chronic Heart Failure Reduces Bi-Directional Pulmonary Fluid Flux2012 · 21 citations
  4. 4Myocardial Dysfunction with Increased Ventricular Compliance in Volume Overload Hypertrophy2006 · 17 citations
  5. 5Functional Improvement and Regression of Medial Hypertrophy in the Remodeled Pulmonary Artery after Correction of Systemic Left-to-Right Shunt2016 · 8 citations