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May 14, 2026JBMR PlusOpen Access

Bone Fragility in a Post-Intestinal Transplant Patient with Mesenteric Heterotopic Ossification: A Case Report

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Authors

HHHusam HamsharyDBDania Salih BachaLKLeila Khan

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Overview

Case report reveals challenges of bone fragility in a post-intestinal transplant patient, suggesting careful management is needed.

Key Points

  • To discuss the occurrence of heterotopic ossification in the mesentery and its implications for bone fragility post-intestinal transplantation.
  • Case examination of a 44-year-old man with mesenteric heterotopic ossification following abdominal surgeries
  • Histopathological analysis of bone formation in mesenteric tissues
  • Long-term management with zoledronic acid followed by denosumab for bone fragility
  • Patient developed multiple vertebral compression fractures post-transplant due to chronic medication effects
  • Stabilization of bone mineral density was achieved after over a decade of zoledronic acid treatment
  • Successful transition to denosumab without new fractures occurring thereafter

Cite This Study

Hamshary et al. (2026) studied this question.

synapsesocial.com/papers/6a0567fda550a87e60a2042fhttps://doi.org/10.1093/jbmrpl/ziag082
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