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May 14, 2026Physiology

Distinct Cardiometabolic Stressors Differentially Regulate Bone Marrow Myeloid Progenitors

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Authors

VTVeronica TorresXRXavier ReveloHRHai‐Bin Ruan

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Overview

Randomized trial shows that different cardiometabolic stressors impact myeloid progenitor levels in mice, suggesting tailored approaches for metabolic diseases.

Key Points

  • This research aims to understand how various cardiometabolic stressors affect myeloid progenitors in the bone marrow.
  • Male C57BL/6J mice were subjected to high-fat diet-induced obesity, intermittent fasting, HFpEF, and TAC-induced heart failure.
  • Flow cytometry was utilized to quantify distinct bone marrow progenitor populations.
  • HFD did not significantly change myeloid progenitor frequencies compared to lean mice, indicating alternative chronic inflammation mechanisms.
  • Intermittent fasting led to a significant reduction in monocyte progenitors (MoPs) amidst obesity.
  • HFpEF caused a substantial increase in multiple myeloid progenitor populations like LSKs, CMPs, GMPs, MoPs, and MDPs.

Cite This Study

Torres et al. (2026) studied this question.

synapsesocial.com/papers/6a05680ea550a87e60a205c9https://doi.org/10.1152/physiol.2026.41.s1.2300451
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Also Consider

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  1. 1Diet‐induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow2016 · 91 citations
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  3. 3Altered bone marrow niche forms central innate immune memory driving cardiac dysfunction2026
  4. 4Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells2014 · 239 citations
  5. 5Diet-induced obesity induces oxidative stress and enhances H3K4me3 levels, driving nonresolving inflammation and myelopoiesis in hematopoietic stem and progenitor cells2025 · 9 citations