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May 14, 2026Physiology

Impact of Extrinsic Sleep Disruption During Pregnancy and the Postpartum Period on Systemic and Cardiovascular Adaptations

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Authors

IPIona PalmerNANora AndersonNBNolan Boyd

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Overview

Randomized trial examines cardiovascular changes due to sleep disruption in pregnancy, indicating health risks.

Key Points

  • The study aims to understand how extrinsic sleep disruption affects maternal cardiovascular adaptations during pregnancy and postpartum.
  • Utilized 12-week-old C57BL/6N female mice, examining various pregnancy stages from non-pregnancy to postpartum.
  • Assessed systemic metabolism and rest/activity patterns using indirect calorimetry.
  • Simulated shiftwork through altered light/dark cycles to study sleep disruption effects.
  • Significant changes in respiratory exchange ratio, energy expenditure, and locomotion patterns during mid-pregnancy and postpartum (p<0.001).
  • Elevated expression of circadian and metabolic transcripts correlated with maternal physiological adaptations.
  • Shiftwork significantly disrupted pregnancy-related sleep patterns, impacting calorimetry parameters.

Cite This Study

Palmer et al. (2026) studied this question.

synapsesocial.com/papers/6a05685ca550a87e60a20dabhttps://doi.org/10.1152/physiol.2026.41.s1.2298333
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circadian patterns of behaviour change during pregnancy in mice2024 · 2 citations
  2. 21978-LB: Sleep Duration during Pregnancy and Cardiometabolic Biomarkers—A Multiracial Pregnancy Cohort2024 · 1 citations
  3. 3Differential effects of postpartum sleep restriction on maternal and offspring immunity in the rat2025
  4. 4Autonomic and Renal Alterations in the Offspring of Sleep-Restricted Mothers During Late Pregnancy2016 · 13 citations
  5. 52136-P: Gestational Circadian Disruption Impairs Glucose Metabolism in Adult Offspring Mice2026