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May 14, 2026

Optic nerve diameter in early-stage idiopathic Parkinson's disease: A prospective observational study.

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Authors

OKOsman KorucuAYArif Ülkü YenerSASelcan Ekicier Acar

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Overview

Prospective observational study compares optic nerve sheath diameter in early-stage IPD and healthy individuals, indicating its limited value as a biomarker.

Key Points

  • This study aimed to assess optic nerve sheath diameter in early-stage idiopathic Parkinson's disease compared to healthy controls.
  • Prospective observational study of 100 patients with early-stage IPD and 50 healthy controls.
  • Comprehensive ophthalmologic examination and B-scan ultrasonography used to measure optic nerve sheath diameter.
  • Statistical analyses performed using non-parametric tests for significance.
  • No significant differences in optic nerve sheath diameter between early-stage IPD patients and healthy controls (P > .05).
  • Subgroup analyses revealed no stage-dependent differences in optic nerve sheath diameter measurements.
  • Findings suggest that optic nerve sheath diameter may have limited value as a biomarker in the early stages of Parkinson's disease.

Cite This Study

Korucu et al. (2026) studied this question.

synapsesocial.com/papers/6a05685ca550a87e60a20e27https://doi.org/10.1097/md.0000000000048676
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MRI-Based Texture Analysis of the Extraocular Optic Nerve in Idiopathic Parkinson’s Disease2026
  2. 2Influence of age on the thickness of retinal nerve fiber layer in patients with mild-to-moderate stages of Parkinson’s disease: Case series2024
  3. 3Structural changes in the retina as a potential biomarker in Parkinson's disease: an approach from optical coherence tomography2024 · 15 citations
  4. 4Optic Nerve Sheath Diameter Measurement: Preliminary Findings in Ischemic Stroke Patients2026 · 1 citations
  5. 5Changes in Visual Evoked Potential and Optical Coherence Tomography in Parkinson’s Disease: A Systematic Review and Meta‐Analysis2025