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May 14, 2026Organic & Biomolecular Chemistry0 citations

Identification of two multifunctional P450 enzymes for biosynthesis of sesteraltererol-type sesterterpenoids

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YLYue LiuZGZhuo-Jia GanZZZhong-Yuan Zhang

Key Points

  • This research aims to identify and characterize multifunctional P450 enzymes involved in the biosynthesis of sesteraltererol-type sesterterpenoids.
  • Identified a five-gene cluster related to sesteraltererol biosynthesis.
  • Characterized the enzyme AasA and compared it with another known terpene synthase, AaTPS1.
  • Analyzed the catalytic processes of these enzymes in producing sesterterpenoids.
  • AasA catalyzes the formation of sesteraltererol, similar to AaTPS1.
  • Demonstrated the involvement of other multifunctional P450 enzymes in sesterterpenoid biosynthesis.
  • Showed that the five-gene cluster is essential for efficient production of sesteraltererol-type compounds.

Abstract

A five-gene cluster for biosynthesis of sesteraltererol-type sesterterpenoids were identified. Among them, the sesterterpene synthase AasA catalyzes formation of sesteraltererol as the known terpene synthase AaTPS1, and then two multifunctional...

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a05685ca550a87e60a20e5dhttps://doi.org/10.1039/d6ob00650g
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